Exercise therapy for fatigue in multiple sclerosis. Heine M, Van dP I, Rietberg MB, van Wegen EE, Kwakkel G. Symptom change with exercise is a temporary phenomenon for people with multiple sclerosis.

Smith RM, ey-Steel M, Fulcher G, Longley WA. 2014 15(343 (1-2)):3–7 Comprehensive review showing that exercise is safe in MS and that exercise positively impact relapse rate. The safety of exercise training in multiple sclerosis: a systematic review. Pilutti LA, Platta ME, Motl RW, Latimer-Cheung AE.Multiple sclerosis and physical activity : an historical perspective. Exercise as medicine in multiple sclerosis - moving beyond compensatory benefits. Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases. Exercise in patients with multiple sclerosis. Motl RW, Sandroff BM, Kwakkel G, Dalgas U, Feinstein A, Heesen C, et al. Comparative efficacy and acceptability of disease-modifying therapies in patients with relapsing-remitting multiple sclerosis: a systematic review and network meta-analysis. Treatment of cognitive impairment in multiple sclerosis: position paper. 2014 2014:798285–12.Īmato MP, Langdon D, Montalban X, Benedict RH, DeLuca J, Krupp LB, et al. Meta-analysis of three different types of fatigue management interventions for people with multiple sclerosis: exercise, education, and medication. The clinical meaning of walking speed as measured by the timed 25-foot walk in patients with multiple sclerosis. 2018 363:k4674.Ĭohen JA, Krishnan AV, Goodman AD, Potts J, Wang P, Havrdova E, et al. Disease-modifying therapies for multiple sclerosis. Geneva: World Health Organization 2006.ĭe Angelis F, John NA, Brownlee WJ. Neurological disorders : public health challenges.

New insights into the burden and costs of multiple sclerosis in Europe. Kobelt G, Thompson A, Berg J, Gannedahl M, Eriksson J, Group MS, et al. Multiple Sclerosis Journal - Experimental, Translational and Clinical. Costs and quality of life by disability among people with multiple sclerosis: a register-based study in Sweden. Gyllensten H, Kavaliunas A, Alexanderson K, Hillert J, Tinghog P, Friberg E.

Natural history of multiple sclerosis symptoms. Kister I, Bacon TE, Chamot E, Salter AR, Cutter GR, Kalina JT, et al. Underlying cause of death in Danish patients with multiple sclerosis: results from the Danish Multiple Sclerosis Registry. Koch-Henriksen N, Bronnum-Hansen H, Stenager E. Survival and cause of death in multiple sclerosis: a 60-year longitudinal population study. Lunde HMB, Assmus J, Myhr KM, Bo L, Grytten N. Age and disability accumulation in multiple sclerosis. Scalfari A, Neuhaus A, Daumer M, Ebers GC, Muraro PA. Liguori M, Marrosu MG, Pugliatti M, Giuliani F, De RF, Cocco E, et al. Modern multiple sclerosis treatment - what is approved, what is on the horizon. Atlas of multiple sclerosis 2013: a growing global problem with widespread inequity. 2008 372(9648):1502–17.īrowne P, Chandraratna D, Angood C, Tremlett H, Baker C, Taylor BV, et al. Papers of particular interest, published recently, have been highlighted as: Ĭompston A, Coles A. Summaryīased on recent evidence, a new paradigm shift is proposed, in which exercise at an early stage should be individually prescribed and tailored as “medicine” to persons with MS, alongside conventional medical treatment. Initial studies established exercise as an effective symptomatic treatment (i.e., tertiary prevention), but recent studies have evaluated the disease-modifying effects (i.e., secondary prevention) of exercise as well as the impact on the risk of developing MS (i.e., primary prevention). The aim of this review is to summarize the existing knowledge of the effects of exercise as primary, secondary, and tertiary prevention in MS. However, having been found to be safe and effective, exercise has become a cornerstone of MS rehabilitation and may have even more fundamental benefits in MS, with the potential to change clinical practice again. For many years, exercise was controversial in multiple sclerosis (MS) and thought to exacerbate symptoms and fatigue.

Physical activity paradigm shift